"HIF-1?± is a key element of the signaling cascade that promotes tumor growth and metastases in a wide range of cancers," said Ivan Horak, MD, Enzon's President of Research and Development and Chief Scientific Officer. "These two Phase I studies build on a growing body of clinical and preclinical evidence demonstrating the potential of both EZN-2968 and EZN-2208 to inhibit this important target. We look forward to collaborating with the NCI in further understanding the promise demonstrated by these two product candidates."

The EZN-2968 study is expected to enroll 22 patients with solid tumors, predominantly involving the liver. EZN-2968 will be administered as a two-hour intravenous infusion once a week for three consecutive weeks, followed by a three-week period without drug. Tumor biopsies and other correlative imaging and pharmacodynamic studies will be performed at baseline and after drug administration.

The EZN-2208 study is expected to enroll 20 patients with solid tumors whose disease has progressed following standard therapy, or who have no acceptable standard treatment. EZN-2208 will be administered intravenously on days one, eight, and fifteen of a 28-day cycle. Avastin will be administered intravenously every two weeks. Tumor biopsies and other correlative imaging and pharmacodynamic studies will be performed at baseline and after drug administration.

Source: Enzon Pharmaceuticals, Inc